Ram pressure stripping is a key process by which galaxies in clusters evolve, on a base level, stripping away gas and consequently quenching star formation. I will present evidence from recent observations with high resolution instruments, including HST and ALMA, of the direct influence and effects of ram pressure on the dense ISM of two galaxies: D100 in the Coma cluster, and NGC 4402 in the Virgo cluster. The dense ISM is of particular interest because it is the birthplace of star formation. We find direct observational evidence supporting both the compression of molecular gas, possibly triggering a starburst, and of direct stripping of molecular gas via momentum transfer. Our evidence of these effects on the ISM due to RPS allow us to investigate how the ISM in RPS galaxies evolves, and presents a more complex picture than simple quenching. Furthermore, I will present analysis based on HST observations of D100, a galaxy with an extremely long and narrow (60 x 2 kpc) H-alpha tail, of the properties of stars formed in the tail, and the stellar population of the disk of the galaxy, and what it reveals about the evolution of D100 under ram pressure.